Russia make three changes to the side that defeated Egypt, including dropping Golovin to the bench as he is on a yellow card. Smolnikov, Kudryashov and Miranchuk all come in. Cheryshev has been the star of the show for the hosts so far, netting three goals in two matches.
Uruguay make four changes to the side that defeated Saudi Arabia, with Coates, Nandez, Laxalt and Torreira all starting. Varela, Sanchez and Rodriguez drop out, while Jose Gimenez misses out through injury.
Muslera earns his 100th cap for Uruguay between the sticks.
Russia subs: Andrey Lunev, Vladimir Gabulov, Daler Kuzyaev, Vladimir Granat, Aleksandr Golovin, Fedor Smolov, Andrey Semenov, Aleksandr Erokhin, Mario Fernandes, Yuri Zhirkov, Anton Miranchuk.
Uruguay subs: Martin Campana, Martin Silva, Cristian Rodriguez, Maxi Gomez, Guillermo Varela, Cristhian Stuani, Giorgan de Arrascaeta, Carlos Sanchez, Gaston Silva, Jonathan Urretaviscaya, Maxi Pereira.
Russia XI: Igor Akinfeev; Igor Smolnikov, Ilya Kutepov, Sergei Ignashevich, Fedor Kudryashov; Roman Zobnin, Yuri Gazinskiy; Aleksandr Samedov, Aleksey Miranchuk, Denis Cheryshev; Artem Dzyuba.
Uruguay XI: Fernando Muslera; Sebastian Coates, Diego Godin, Martin Caceres; Lucas Torreira; Nahitan Nandez, Matias Vecino, Rodrigo Bentancur, Diego Laxalt; Luis Suarez, Edinson Cavani.